Polynucleotides,
rebuilt from within
Advanced skin repair that works with your body’s own biology — the PLINEST® and NEWEST® range, administered in person by our registered nurse.
Skin repair,
from the inside out
Polynucleotides are one of the most exciting developments in aesthetic medicine in recent years, and one of our favourite treatments to offer. In simple terms, they are chains of highly purified DNA — derived from trout — that act as a powerful signal to your skin cells, telling them to repair, regenerate and produce more of the building blocks that keep skin looking healthy and youthful.
You may have come across the term PDRN. Polynucleotides (PN) and PDRN are closely related, but they aren’t quite the same: PDRN refers to shorter DNA fragments, whereas polynucleotides are longer, higher-molecular-weight chains. We use the PLINEST® and NEWEST® range by Mastelli, made using HPT® (High Purification Technology) — one of the most refined and extensively researched polynucleotide platforms available. Those longer chains and exceptional purity mean a stronger regenerative signal for your skin, and an outstanding safety profile.
Unlike treatments that simply fill or relax, polynucleotides work at a deeper biological level — improving the quality and health of your skin tissue over time. Think of it less as a quick fix and more as a long-term investment in the health of your skin.
“Polynucleotides are one of the few treatments where we consistently see clients surprised by how their skin feels, not just how it looks — softer, more hydrated, and genuinely healthier.”
Charlotte · Lead Aesthetics NursePLINEST® & NEWEST®
Polynucleotides are delivered via a series of small injections just beneath the surface of the skin, and can be used on the face, neck, décolletage and hands. Because the molecules are so highly purified, the risk of adverse reactions is exceptionally low.
Within the range, we choose the formulation to suit your skin and the area being treated. PLINEST® is our go-to for overall skin quality and regeneration, with a dedicated formulation for the delicate under-eye area. NEWEST® combines polynucleotides with hyaluronic acid for an added boost of hydration and support where the skin needs a little more.
A signal, not a filler
Your skin is made up of cells that constantly renew and repair. With age — and as a result of sun exposure, stress and lifestyle — this process slows: the skin makes less collagen and elastin, holds less moisture, and takes longer to repair itself. Polynucleotides act as a biostimulator, switching on that repair process rather than adding anything foreign.
Stimulate fibroblasts
The cells responsible for producing collagen and elastin — which give skin its firmness and bounce.
Improve hydration
By increasing the skin’s ability to retain moisture at a cellular level, not just on the surface.
Promote tissue repair
Particularly effective for skin damaged by sun exposure, scarring, or the natural ageing process.
Reduce inflammation
A calming effect on inflamed or reactive skin — why they work so well for rosacea-prone or sensitive skin.
What it can improve
One of the most versatile rejuvenation treatments available, because it improves skin quality at a fundamental level rather than targeting one specific issue.
Deep hydration
Improves the skin’s ability to hold moisture from within, for a plumper, dewier look that doesn’t fade by the end of the day.
Skin texture
Smooths uneven texture, reduces the appearance of enlarged pores, and refines the skin surface over time.
Fine lines
Softens superficial fine lines — particularly the crêpey lines around the eyes and mouth that fillers can’t always reach.
Sun damage
One of the most effective treatments for the effects of sun damage — improving tone, reducing discolouration, repairing texture.
Skin laxity
Helps firm and tighten skin that has lost elasticity — particularly on the neck, jawline and under-eye area.
Sensitive skin
The anti-inflammatory action makes this one of the few injectables suited to reactive, rosacea-prone or easily-irritated skin.
Who it suits
- Anyone noticing their skin feels drier or less radiant than it used to
- People with fine lines and crêpey skin around the eyes, mouth or neck
- Those with sun-damaged or uneven skin tone
- Sensitive or reactive skin types, including rosacea-prone skin
- Anyone wanting to complement existing anti-wrinkle or filler treatments
- Those in their 30s–60s looking for gradual, natural improvement
- Post-acne scarring, or skin that has been through a difficult period
- You are pregnant or breastfeeding
- You have a known fish or seafood allergy (the polynucleotides are trout-derived)
- You have an active skin infection or cold sore in the treatment area
- You are taking blood-thinning medication (please discuss with us first)
- You have certain autoimmune conditions (we’ll review this at consultation)
Your appointment
Preparation
No special preparation is needed. Come with a clean face if possible — no thick moisturiser or makeup on the area. Avoid alcohol the night before and stay well hydrated. If you’re prone to bruising, avoid ibuprofen and aspirin for 48 hours if you’re able.
Consultation & assessment
We sit down together and talk through your skin concerns, medical history and what you’re hoping to achieve, then assess your skin in good lighting. There’s no rush — this conversation matters as much as the treatment itself.
Topical numbing
A numbing cream is applied and left to work for around 15 minutes. Most clients find the injections very comfortable, but we use numbing cream as standard — your comfort matters.
The treatment
Using a very fine needle, the polynucleotides are placed just beneath the skin in a series of small, precise injections across the area. You’ll feel mild pressure and possibly a slight tingle. Usually 20–30 minutes.
Recovery & aftercare
You may notice small bumps or mild redness at the injection sites — completely normal, and usually settled within a few hours. We go through your aftercare and book any follow-up before you leave.
When you’ll see it
Polynucleotides work gradually — the results reflect what is actually happening in your skin biologically, so they build over time and look entirely natural. People often notice something has changed about your skin without being able to pinpoint what.
Possible mild redness or small bumps at injection sites. Skin may feel slightly firmer immediately after.
Improved hydration becomes noticeable. Skin starts to feel softer and more comfortable.
Visible improvements in texture and glow; fine lines begin to soften. Typically when the compliments start.
Full results following a course. Significant improvement in skin quality, firmness and overall appearance.
The first few days
Avoid touching the area
Keep hands away from the treated skin for at least six hours after your appointment.
Keep it simple
Gentle, fragrance-free skincare for the first 48 hours. No active ingredients (retinol, AHAs, BHAs) for 3–5 days.
Sun protection is essential
Apply SPF 30 or higher daily — important both for your results and your skin’s long-term health.
No facials or massage
Avoid facial massage, microneedling or other skin treatments for at least two weeks.
Avoid heat
No saunas, steam rooms or intense exercise for 24–48 hours, as heat can increase swelling.
Stay hydrated
Drink plenty of water in the days after — hydration supports your skin’s repair process.
Limit alcohol
Avoid alcohol for 24 hours, as it can increase bruising and slow recovery.
Any concerns, contact us
We’re always available to answer questions after your treatment — please don’t hesitate to get in touch.
One of the safest injectables
Polynucleotides have an excellent safety profile and are considered one of the safest injectable treatments available. The highly purified formulations used in medical aesthetics undergo stringent testing and have been used widely across Europe and Asia for many years.
- A thorough medical history and skin assessment at every consultation
- We won’t proceed if we have any clinical concern
- Fully trained in the management of complications, with an emergency kit at every appointment
- Because the molecules are so highly purified, adverse reactions are exceptionally uncommon
- Common effects are mild and temporary — brief redness, small bumps, occasional bruising or tenderness
- Any unusual symptoms after treatment — you can reach us directly
Not a quick fix —
a long-term investment
Polynucleotides don’t fill or freeze; they improve the quality of your skin over time. We use the PLINEST® and NEWEST® range by Mastelli, made with HPT® High Purification Technology — longer-chain, higher-purity polynucleotides than generic, first-generation PDRN. We’ll always give you a realistic, honest picture of what a course can achieve at your consultation, and tell you if something else would serve your skin better.
Good to ask
The other clearings
Ready to invest in
your skin’s health?
Book a consultation and we’ll give you an honest view of what polynucleotides can do for your skin — and whether they’re the right place to start.
Book a Consultation